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No. Title Journal Vol.(No), Page Year Author
49 フラーレンの目立つ毛穴の減少：PGE2を介したメカニズムの可能性 Medical Science Digest 42(14), 42-44 2016 Aoshima H. et al.
48 Potential suppressive effects of C60-fullerene derivatives on acquired immunity. Nanoscale Research Letters Accepted 2016 Hirai T. et al.
47 Protective effects of polyvinylpyrrolidone-wrapped fullerene against intermittent ultraviolet-A irradiation-induced cell injury in HaCaT cells Journal of Photochemistry & Photobiology, B: Biology 163 (2016) 22-29 2016 Yasukazu S. et. al.
46 Hydroxylated Fullererne : a potential anti-inflammatory and anti-oxidant agent for preventing mouse preterm birth American Journal of Obstetrics & Gynecology. 213(5), 708-717 2015 Wakimoto T. et al.
No. Title Journal Vol.(No), Page Year Author
45 Reduction of conspicuous facial pores by topical fullerene: possible role in the suppression of PGE2 production in the skin Journal of Nanobiotechnology 12, 6 2014 Inui S. et al.
44 Fullerene-C60 derivatives prevent UV-irradiation/TiO2-induced cytotoxicity on keratinocytes and 3D-skin tissues through antioxidant actions. Journal of Nanoscience and Nanotechnology 14, 3285-3291 2014 Kato S. et al.
No. Title Journal Vol.(No), Page Year Author
43 Photoprotective effects of inclusion complexes of fullerenes with polyvinylpyrrolidone. Photodermatol Photoimmunol Photomed 29(4), 196-203 2013 Murakami M et al.
42 Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration. Pharmazie 68(1), 54-57 2013 Yamashita K. et al.
No. Title Journal Vol.(No), Page Year Author
38 フラーレンの抗酸化機能と化粧品への応用／フラーレンの安全性に関する最新知見と評価 Bio Industry　3月号 29,3,39-45 2012 Aoshima H.／Ito M.
39 Polyhydroxylated fullerene C60(OH)44 suppresses intracellular lipid accumulation together with repression of intracellular superoxide anion radicals and subsequent PPARγ2 expression during spontaneous differentiation of OP9 preadipocytes into adipocytes. Mol Cell Biochem 366, 191-200 2012 Saitoh Y. et al.
40 Inhibition of sebum production and propionibacterium acnes lipase activity by fullerenol, a novel polyhydroxylated fullerene: Potential as therapeutic reagent for acne. The Journal of Cosmetic Science 63, 259-265 2012 Inui S. et al.
41 Induction of different reactive oxygen species in the skin during various laser therapies and their inhibition by fullerene. Lasers Surg Med. 44(8), 685-694 2012 Fujimoto T. et al
No. Title Journal Vol.(No), Page Year Author
35 Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nature Nanotechnology 6(5)321-238 2011 Yamashita K. et al.
36 Fullerene-C60 incorporated in liposome exerts persistent hydroxyl radical-scavenging activity and cytoprotection in UVA/B-irradiated keratinocytes Journal of Nanoscience and Nanotechnology 11(5), 3814-3823 2011 Kato S. et al.
37 Highly Hydroxylated Fullerene localizes at Cytoskeletons and inhibits Oxidative stress in Adipocytes and a Subcutaneous Adipose-tissue Equivalant Free Radic Biol Med 51(7), 1376-89 2011 Xiao, L. et al.
No. Title Journal Vol.(No), Page Year Author
22 Fullerene-C60/liposome complex: defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue. Journal of Photochemistry and Photobiology B: Biology 98, 99-105 2010 Kato S. et al.
23 Defensive effects of fullerene-C60 dissolved in squalane against the 2, 4-nonadienal induced cell injury in human skin keratinocytes HaCaT and wrinkle formation in 3D-human skin tissue model. Journal of Biomedical Nanotechnology 6, 1-7 2010 Kato S. et al.
24 Defensive effects of fullerene-C60/liposome complex against UVA-induced intracellular reactive oxygen species generation and cell death in human skin keratinocytes HaCaT, associated with intracellular uptake and extracellular excretion of fullerene-C60. Journal of Photochemistry and Photobiology B: Biology 98, 144-151 2010 Kato S. et al.
25 Biological safety of water-soluble fullerenes evaluated by genotoxicity, phototoxicity studies, and pro-oxidant activity. The Journal of Toxicological Science 35 (3), 401-409 2010 Aoshima H. et al.
26 The effect of squalane-dissolved fullerene-C60 on adipogenesis-accompanied oxidative stress and macrophage activation in a preadipocyte-monocyte co-culture system. Biomaterials. 31, 5976-5985 2010 Xiao, L. et al
27 Clinical Evaluation of Fullerene-C60 Dissolved in Squalane for Anti-Wrinkle Cosmetics. Journal of Nanoscience and Nanotechnology 10, 6769-6774 2010 Kato S. et al.
28 水酸化フラーレンナノ粒子の合成方法とその応用～化粧品用添加剤から杉花粉アレルゲン除去まで～ 化学装置 7月号, 49-53 2010 Kokubo K. et al.
29 フラーレン(C60)の関節炎に対する抗炎症・破骨細胞分化・機能抑制効果 グルコサミン研究 6, 61-67 2010 Aooshima H. et al.
30 Novel polyhydroxylated fullerene suppresses intracellular oxidative stress together with repression of intracellular lipid accumulation during the differentiation of OP9 preadipocytes into adipocytes. Free Radical Research 44(9), 1072-1081. 2010 Saitoh Y. et al.
31 Fullerene-Polyvinylpyrrolidone Clathrate Localizes in the Cytoplasm to Prevent Ultraviolet-A Ray-Induced DNA-Fragmentation and Activation of the Transcriptional Factor NF-kappa B Journal of Cellular Biochemistry 9999, 1-12 2010 Xiao, L. et al.
32 Improvement of acne vulgaris by topical fullerene application: Unique impact on skin care Nanomedicine: Nanotechnology, Biology, and Medicine. 7, 238-241 2010 Inui S. et al.
33 Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages. Journal of Photochemistry and Photobiology B: Biology. 102, 69-76 2010 Saitoh Y. et al.
34 Facile and Scalable Synthesis of Highly Hydroxylated Water-Soluble Fullerenol as a Single Nanoparticle. Free Radic Biol Med 4(2), 204-215 2010 Kokubo K. et al.
No. Title Journal Vol.(No), Page Year Author
14 抗酸化成分フラーレンの事業化 未来材料 9, 1, 63-65 2009 Yamana S., Ito M.
15 Biological Safety of LipoFullerene composed of Squalane and Fullerene-C60 upon Mutagenesis, Photocytotoxicity, and Permeability into the Human Skin Tissue. Basic & Clinical Pharmacology & Toxicology 104(6), 483-487 2009 Kato S. et al.
16 Biological safety of liposome-fullerene consisting of hydrogenated lecithin, glycine soja sterols, and fullerene-C60 upon photocytotoxicity and bacterial reverse mutagenicity. Toxicology and Industrial Health 25(3), 197-203 2009 Kato S. et al.
17 Antimicrobial Activity of Fullerenes and Their Hydroxylated Derivatives Biocontrol Science 14 (2), 69-72 2009 Aoshima H. et al.
18 Highly-hydroxylated or g-cyclodextrin-bicapped water-soluble derivative of fullerene: the antioxidant ability assessed by electron spin resonance method and b-carotene bleaching assay. Bioorganic & Medicinal Chemistry Letters 19 (18), 5293 2009 Kato S. et al.
19 Safety evaluation of highly purified fullerenes: based on screening of eye and skin damages. The Journal of Toxicological Science 34 (5), 555-562 2009 Aoshima H. et al.
20 フラーレン類の抗酸化能評価および汎用化粧品成分の光分解抑制効果 日本香粧品学会誌 33 (3), 149-154 2009 Aoshima H. et al.
21 Preparation of Hydrophilic Nanoparticles of C60 with High Resistance to Aggregation during Storage, using 2-Hydroxypropyl-b-cyclodextrin. Chemistry Letters 38 (11), 1104-1105 2009 Iohara D. et al.
No. Title Journal Vol.(No), Page Year Author
13 Facile synthesis of highly water-soluble fullerenes more than half-covered by hydroxyl groups ACS NANO 2, 2, 327-333 2008 Kokubo K. et al.
No. Title Journal Vol.(No), Page Year Author
10 Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVA-induced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues Archives of Dermatological Research 299, no5-6, 245-257 2007 Xiao, L. et al.
11 Water-soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis via down-regulation of chondrocyte catabolic activity and inhibition of cartilage degeneration during disease development Arthritis and Rheumatism 56, 10, 3307-3319 2007 Yudoh K. et al.
12 Involvement of free radicals followed by the activation of phospholipase A2 in the mechanism that underlies the combined effects of methamphetamine and morphine on subacute toxicity or lethality in mice: Comparison of the therapeutic potential of fullerene, mepacrine, and cooling Toxicology 236, 3, 149-57 2007 Mori, T. et al
No. Title Journal Vol.(No), Page Year Author
6 The Water-Soluble Fullerene Derivative "Radical Sponge・Exerts Cytoprotective Action against UVA Irradiation but Not Visible-Light-Catalyzed Cytotoxicity in Human Skin Keratinocytes Bioorganic & Medicinal Chemistry Letters 16, 1590-1595 2006 Xiao, L. et al
7 Preclinical Studies on Safety of Fullerene upon Acute Oral Administration and Evaluation for No Mutagenesis Toxicology 225, 48-54 2006 Mori, T. et al
8 Innovative Anti-Oxidant: Fullerene(INCI#: 7587) is as Radical Sponge on the skin. Its High Level of Safety, Stability and Potential as Premier Anti-Aging and Whitening Cosmetic Ingredient Fullerenes, Nanotubes, and Carbon Nanostructures 14, 335-341 2006 Takada, H. et al.
9 Antioxidant Activity of Supramolecular Water-soluble Fullerenes Evaluated by β‐Carotene Bleaching Assay Bioscience, Biotechnology, and Biochemistry, Oct/2006 70, 12, 3088-3093 2006 Takada, H. et al.
No. Title Journal Vol.(No), Page Year Author
5 Anti-Oxidant Effects of Water-soluble Fullerene Derivatives against Ultraviolet Ray or Peroxylipid through Their Action of Scavenging the Reactive Oxygen Species in Human Skin Keratinocytes Biomedicine & Pharmacotherapy 59, 351-358 2005 Xiao, L. et al
No. Title Journal Vol.(No), Page Year Author
4 ナノテクノロジー素材フラーレン誘導体の抗酸化作用 新有用性化粧品の開発 -Technology of Evidence Based Cosmetics- 第6章, 291-308 2004 Takada, H. et al.
No. Title Journal Vol.(No), Page Year Author
1 ナノテク素材フラーレン誘導体の抗酸化効果 Fragrance Journal 32, 40-48 2003 Maeda, K. et al.
2 ナノテクノロジー新素材：フラーレンを用いた化粧品による美肌革命の可能性 BIO INDUSTRY 20, 82-90 2003 Matsubayashi, K. et al.
3 フラーレン誘導体による活性酸素の消去－ナノテク新素材の美肌化粧品への応用－ 美肌・皮膚防御とバイオ技術-Rejuvenation and Skin Protection, and Biotechnology- 第4編, 第20章, 229-238 2003 Miwa, N. ed.