List of Conference Presentation & Publications
Key publications and presentations on our research and development.
| 2023 | フェアリー化合物（2-aza-8-oxohypoxanthine）のB16メラノーマ細胞に対する紫外線傷害防御効果およびメラニン産生抑制効果 Suppressive effects of 2-aza-8-oxohypoxanthine on UV-induced cell injury and melanogenesis in B16 cells |
齋藤 靖和 日本農芸化学会 広島 2023/3/14-17 |
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| 2022 | Topical Application of 2-Aza-8-oxohypoxanthine-Containing Lotion Recovers Skin Barrier Function Following Laser Therapy | Takahiro Fujimoto ASLMS SanDiego 2022/4/28-30 |
| 2021 | フェアリー化合物（2-aza-8-oxohypoxanthine）のヒト皮膚バリア機能回復効果および安全性 | 青島 央江 日本美容皮膚科学会（優秀演題賞受賞） 京都 2021/8/1 |
| 2021 | フェアリー化合物（2-aza-8-oxohypoxanthine）のヒト皮膚バリア機能回復効果および安全性 | 青島 央江 日本抗加齢医学会 京都 2021/6/26 |
| 2020 | ヒト皮膚に対するフェアリー化合物（AOH）の有効性・安全性 | 青島 央江 日本農芸化学会 福岡 2020/3/26 |
| 2018 | PVP包接フラーレンC60の抗酸化作用を利用した化粧品原料への応用 | Hisae Aoshima 日本高分子学会 ポリマー材料フォーラム Chiba 2018/11 |
| 2017 | 皮膚の光老化に対するフラーレンの有効性～抗炎症作用およびカルボニル化タンパク質の生成抑制～ | Hisae Aoshima 第70回日本酸化ストレス学会 Tsukuba 2017/6/28-29 |
| 2016 | Protection by fullerene for hair shaft and wig fiber damage by UV and cosmetic treatments | Masayuki Ito The 4th Eastern Asia Dermatology Congress Tokyo 2016/11/16-18 |
| 2016 | Availability of fullerene for skin photo-aging; Anti-inflammatory and suppression of carboxylated protein generation. | Hisae Aoshima 51th The Fullerenes, Nanotubes and Graphene Research Society Sapporo 2016/9/7 |
| 2016 | Availability and Safety of Fullerene for Skin Photoaging, 17th Annual Meeting of Society of Photoaging Research. | Hisae Aoshima 17th Society for Photoaging Research Kobe 2016/8/20 |
| 2015 | Safety Evaluation of Fullerene and Development of New Drugs Containing Fullerene Derivatives. | Hisae Aoshima NT15 Satellite Symposium Nagoya 2015/6/28 |
| 2015 | フラーレンによる目立つ毛穴の減少：PGE2産生抑制を介したメカニズムの可能性 | 青島 央江 第15回 日本抗加齢医学会総会 福岡 2015/5/29-31 |
| 2015 | 酸化ストレスによって起こる角層のバリア機能低下に対するフラーレンの効果 | 古畑 恵美子 日本薬学会 第135年会 兵庫 2015/3/25-28 |
| 2014 | C60フラーレン誘導体の炎症性腸疾患に対する医薬品応用に向けた検討 〜in vivoにおける獲得免疫抑制作用の検討〜 | 吉岡 靖雄 第87回 日本生化学会大会 京都 2014/10/15-18 |
| 2014 | MAPKに注目したC60フラーレン誘導体による抗炎症作用メカニズムの検討 | 佐上 公一 第87回 日本生化学会大会 京都 2014/10/15-18 |
| 2014 | C60フラーレン誘導体の炎症性腸疾患に対する医薬品応用に向けた検討 〜in vitroにおける抗体産生抑制能のメカニズム解明〜 | 植村 瑛一郎 第87回 日本生化学会大会 京都 2014/10/15-18 |
| 2014 | Synthesis of 14C labeled C60 with higher specific radioactivity | T. Tadai APSORC2014 (2014日本放射化学会年会・第58回放射化学討論会） 名古屋 2014/9/11-13 |
| 2014 | ライフサイエンス分野におけるフラーレンの実用化～事業化から今後の展望～ | 青島 央江 ナノカーボンバイオ サテライトシンポジウム 名古屋 2014/9/2 |
| 2014 | プロゲステロン、フラーレンによるTLR2依存的炎症反応への抑制効果 | 脇本 哲 第19回 日本病態プロテアーゼ学会 大阪 2014/8/8-9 |
| 2014 | C60フラーレン誘導体の免疫抑制剤としての有効性評価 ～in vitroにおける評価～ | 平井 敏郎 第30回 日本DDS学会学術集会 東京 2014/7/30-31 |
| 2014 | C60フラーレン誘導体の免疫抑制剤としての有効性評価 ～in vivoにおける評価～ | 植村 瑛一郎 第30回 日本DDS学会学術集会 東京 2014/7/30-31 |
| 2014 | C60フラーレン誘導体の抗炎症メカニズムに関する基礎的検討 | 佐上 公一 第30回 日本DDS学会学術集会 東京 2014/7/30-31 |
| 2014 | C60フラーレン誘導体の体内動態解析に向けた基礎的検討 | 髙橋 秀樹 第30回 日本DDS学会学術集会 東京 2014/7/30-31 |
| 2014 | 酸化ストレスによる角層機能低下に対するフラーレンの効果 | 古畑 恵美子 第32回日本美容皮膚科学会総会 千葉 2014/7/12-13 |
| 2014 | Fullerene C60 derivatives suppress the acquired immune responses | Yasuo YOSHIOKA Immunology 2014 Pittsburg 2014/5/2-5 |
| 2012 | The basic safety assessment of fullerenol C60 after oral exposure | 山下 浩平 Society of Environmental Toxicology and Chemistry Asia Pacific Annual Meeting (SETAC) 熊本 2012/9/24-27 |
| 2012 | Safety science of fullerenol C60 for developing nanomedicine 1 -anti-inflammatory effect of fullerenol C60 in vitro- | M. Taira The 6th International Conference on Nanotoxicology (Nanotoxicology 2012) 北京 2012/9/4-7 |
| 2012 | Safety science of fullerenol C60 for developing nanomedicine 2 -safety and efficacy assessment of fullerenol C60 in oral exposure- | M. Aoyama The 6th International Conference on Nanotoxicology (Nanotoxicology 2012) 北京 2012/9/4-7 |
| 2012 | 水酸化フラーレンの安全性確保に向けた経口投与時の生体影響評価 | 山下 浩平 第39回 日本毒性学会学術年会 横浜 2012/7/17-19 |
| 2012 | フラーレンによるシワ形成抑制メカニズムの解明 | 青島 央江 第12回 抗加齢医学会総会 横浜 2012/6/22-24 |
| 2012 | Liposome fullerene as a novel antioxidant for skin treatment | 藤本 幸弘（クリニックF) 第2回EADC 北京 2012/6/13-15 |
| 2012 | 抗炎症機能を有する水酸化フラーレンの開発とその薬物治療の最適化への展開 | 平 茉由 日本薬学会第132年会 札幌 2012/3/28-31 |
| 2012 | 脂質ペルオキシルラジカルに対する水酸化フラーレンの系統的な抗酸化活性評価とそのメカニズムの解明 | Ueno H. 第92回年会 日本化学会 東京 2012/3/27 |
| 2011 | Randomized, Double-Blind, Placebo-Controlled Clinical Testing of Fullerene for the Prevention and Treatment of Wrinkles. | Aoshima H. IFSCC2011 Bangkok/Thailand 2011/12/12-14 |
| 2011 | Effect of Inclusion Complexes of Fullerenes with Polyvinylpyrrolidone on the Skin Barrier. | Hyodo S. IFSCC2011 Bangkok/Thailand 2011/12/12-14 |
| 2011 | C60フラーレンの経口ナノ医薬品としての開発に向けた安全性評価 | 潘 慧燕 第61回日本薬学会近畿支部大会 神戸/兵庫 2011/10/22 |
| 2011 | 紫外線による表皮角化細胞の増殖抑制・角化障害に対するPVP包接フラーレン(Radical Sponge)の改善効果 | 藤川 勇樹 第84回日本生化学会大会 京都 2011/9/22-24 |
| 2011 | 美白臨床試験結果（担当：伊藤） | 伊藤 雅之 第29回 日本美容皮膚科学会 下関/山口 2011/9/10-11 |
| 2011 | 超高度水酸化フラーレンの抗酸化能および紫外線A,B波傷害に対する細胞死防御効果 | 斎藤 靖和 第36回 日本香粧品学会 東京 2011/6/9 |
| 2011 | 二酸化チタンとフラーレン誘導体の併用によるヒト皮膚角化細胞および３次元ヒト皮膚組織モデルにおける紫外線防御効果 | 斎藤 靖和 第36回 日本香粧品学会 東京 2011/6/9 |
| 2011 | 有効かつ安全な経口ナノ医薬の開発に向けたC60フラーレンの安全性評価 | 潘 慧燕 第27回 日本DDS学会 東京 2011/6/9-10 |
| 2011 | フラーレン外用剤の毛成長に対する効果の検討 | 乾 重樹 第11回 日本抗加齢医学会 京都 2011/5/27 |
| 2011 | 尋常性ざ瘡に対するフラーレンの有効性に関する研究 | 乾 重樹 第11回 日本抗加齢医学会 京都 2011/5/27 |
| 2011 | EFFECT OF TOPICAL FULLERENE ON ACNE VULGARIS POTENTIALLY THROUGH SUPPRESSING SEBUM PRODUCTION UNDER OXIDATIVE STRESS: UNIQUE IMPACT ON SKIN CARE | Inui S. 22nd World Congress of Dermatology, The International League of Dermatological Societies ソウル/韓国 2011/5/25 |
| 2011 | ANTI-AGING EFFECT OF FULLERENE OWING TO ITS POTENT ANTIOXIDANT ACTIVITY | Aoshima H. 22nd World Congress of Dermatology, The International League of Dermatological Societies ソウル/韓国 2011/5/24-29 |
| 2011 | 化粧品分野におけるフラーレンの応用研究および実用化 | 竹内 睦 第84回 有機デバイス研究会 名古屋 2011/1/21 |
| 2010 | Mitochondrial 8-Oxoguanine DNA glycosylase (OGG1) regulate the cellular function and survival of osteoarthritic chondrocytes in response to catabolic stresses in osteoarthritis. | Yudoh K. 74th Annual Scientific Meeting (American College of Rheumatology：米国リュウマチ学会） Atlanta/USA 2010/11/6-11 |
| 2010 | Evolution of Fullerene Cosme -New clinical Data and Synergistic Effects with Other Ingredient- | Yamana S. International Cosmetic-Tech Conference & Exhibition 静宜大学/Taiwan 2010/10/21-22 |
| 2010 | Nanomedicine and osteoarthritis: What can we expect for the future? | Yudoh K. 2010 World Congress on Osteoarthritis（国際変形性関節症学会） Brussels/Belgium 2010/9/23-26 |
| 2010 | 尋常性痤瘡に対するフラーレンの有効性に関する研究 | Ito M. 第28回 日本美容皮膚科学会 Tokyo/Japan 2010/8/7-8 |
| 2010 | 無作為化二重盲検マッチドペア比較試験によるフラーレンのシワ改善効果の検証 | Aoshima H. 第10回 抗加齢医学会総会 ※優秀演題賞受賞 Kyoto/Japan 2010/6/11-13 |
| 2010 | アスタキサンチンの併用による抗酸化効果および紫外線傷害抑制効果 | Saito Y. 第35回 日本香粧品学会 Tokyo/Japan 2010/6/3-4 |
| 2010 | リポソーム包含フラーレンの抗酸化活性: UVA/B照射下でのヒドロキシルラジカル消去活性、細胞死防御 | Kato S. 第35回 日本香粧品学会 Tokyo/Japan 2010/6/3-4 |
| 2010 | フラーレンによる尋常性痤瘡に対する効果の検討 | Ito M. 第109回 日本皮膚科学会総会 Osaka/Japan 2010/4/16-18 |
| 2010 | 創薬リード化合物としてのフラーレン | Taira H. 日本化学会 第90春季年会 Osaka/Japan 2010/3/26-29 |
| 2010 | Anti-Oxidant Property of Fullerene is Effective in Skin Whiting. | Fujimoto T. 68th Annual Meeting of the American Academy of Dermatology Miami/USA 2010/3/5-9 |
| 2010 | Fullerene is Effective against Wrinkle. | Fujimoto T. 68th Annual Meeting of the American Academy of Dermatology Miami/USA 2010/3/5-9 |
| 2010 | Effect of Fullerene as an Anti-Oxidant during LASER Therapy. | Fujimoto T. 68th Annual Meeting of the American Academy of Dermatology Miami/USA 2010/3/5-9 |
| 2010 | 関節炎治療分野におけるフラーレンの応用：炎症・破骨細胞分化・関節炎抑制効果 | Aoshima H. 第2回 ナノ・バイオメディカル学会 Osaka/Japan 2010/2/22 |
| 2010 | フラーレン(C60)の関節炎に対する抗炎症・破骨細胞分化・機能抑制効果 | Aoshima H. 第6回 グルコサミン研究会 Tokyo/Japan 2010/1/8 |
| 2009 | フラーレン・フロントライン（最新の研究動向と市場の拡大） | Yamana S. 日経ヘルス ビジネスカンファレンス Tokyo/Japan 2009/11/12 |
| 2009 | Fullerenes for Radical Control of your life. | Yamana S. In-Cosmetics Asia Innovation Seminar Singapore/Singapore 2009/10/13-15 |
| 2009 | Evaluation of the Protective Effect of Fullerene-Containing Squalane on Human Skin Cells and Safety of Its Use in Cosmetics. | Taira H. IFSCC Melbourne/Australia 2009/10/7-9 |
| 2009 | Fullerenes for Cosmetics Commercial aspects and practical clues for product development. | Yamana S. International Cosmetic-Tech Conference & Exhibition Taichung/Taiwan 2009/10 |
| 2009 | アスタキサンチン退色抑制能を指標とした抗酸化活性評価法およびアスタキサンチンとフラーレンの活性比較・相乗効果 | Aoshima H. 第5回 アスタキサンチン研究会 Tokyo/Japan 2009/9/18 |
| 2009 | 2-ヒドロキシプロピル-b-シクロデキストリンを用いたフラーレンの親水性ナノ粒子の調製 | Iohara D. 第27回 シクロデキストリンシンポジウム Kanazawa/Japan 2009/9/6-7 |
| 2009 | 新スキンケア素材LipoFullereneの有用性について | Taira H. 第27回 日本美容皮膚科学会・学術大会 Niigata/Japan 2009/8/1-2 |
| 2009 | 水溶性・油溶性フラーレンの抗酸化能および汎用化粧品成分の光分解抑制効果 | Aoshima H. 第27回 日本美容皮膚科学会・学術大会 Niigata/Japan 2009/8/1-2 |
| 2009 | フラーレン外用剤の毛成長に対する効果の検討 | Inui S. 第27回 日本美容皮膚科学会・学術大会 Niigata/Japan 2009/8/1-2 |
| 2009 | Business Development of Fullerenes in Life Science Applications | Yamana S. Fullerenes and Atomic Clusters IWFAC'2009 St Petersburg/Russia 2009/7/6-10 |
| 2009 | Water-soluble fullerene (C60) prevents degeneration of articular cartilage in osteoarthritis (OA): C60 downregulates catabolic activity of chondrocytes and inhibits degeneration of articular cartilage during the development of OA. | Yudoh K. The 9th World Congress on Inflammation (日本炎症・再生医学会合同） Tokyo/Japan 2009/7/6-10 |
| 2009 | ヒドロキシプロピル-b-シクロデキストリンを用いたフラーレン (C60) の水溶性ナノ粒子化 | Iohara D. 第25回 日本DDS学会 Tokyo/Japan 2009/7/3-4 |
| 2009 | リポソーム包含フラーレンによる紫外線A波防御効果 | Kato S. 第34回 日本香粧品学会 Tokyo/Japan 2009/6/11-12 |
| 2009 | 新規３次元セルライト皮膚モデルを用いた、高度水酸化フラーレンのリンパ様細胞U937活性化抑制効果の検証 | Xio L. 第34回 日本香粧品学会 Tokyo/Japan 2009/6/11-12 |
| 2009 | Business Development of Fullerenes in Life Science Applications. | Yamana S. International Academy of Nano Medicine 2009 Hainan/China 2009/6 |
| 2009 | フラーレン外用剤の毛成長に対する効果の検討 | Inui S. 第108回 日本皮膚科学会総会 Fukuoka/Japan 2009/4/24-26 |
| 2009 | The action of Anti-oxidants, Fullerene, on LASER therapy of pigment spots. | Fujimoto T. ASLMS 29th Annual Conference Washington, D.C./USA 2009/4/1-5 |
| 2009 | フラーレンのライフサイエンス分野への応用 －化粧品科学と医薬品開発に関する研究のご紹介－ | Hyodo S. 日本化学会 第89春季年会 Chiba/Japan 2009/3/27-30 |
| 2009 | 親水性シクロデキストリンによる水溶性 C60 ナノ粒子の調製とその凝集安定性 | Iohara D. 第129回年会 日本薬学会 Kyoto/Japan 2009/3/26-27 |
| 2009 | 脂肪細胞分化に伴う脂肪滴蓄積及び細胞内酸化ストレス増大に対する水酸化フラーレン誘導体の抑制効果 | Mizuno/Miwa N. 第129回年会 日本薬学会 Kyoto/Japan 2009/3/26-27 |
| 2009 | ヒト皮膚細胞における酸化ストレス誘導性細胞傷害に対する各種フラーレン誘導体の防御活性 | Miyanishi/Miwa N. 第129回年会 日本薬学会 Kyoto/Japan 2009/3/26-27 |
| 2009 | Business Development of Fullerenes in Life Science Application. | Yamana S. The 36th Fullerene-Nanotubes General Symposium Nagoya/Japan 2009/3/2-4 |
| 2008 | Preparation of Water-Soluble C60 Nanoparticles by Co-grinding with Hydrophilic Cyclodextrin Derivatives | Iohara D. American Pharmaceutical Association Atlanta 2008/11/16-20 |
| 2008 | Water-soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis via down-regulation of chondrocyte catabolic activity and inhibition of cartilage degeneration during disease development | Yudoh K. American College of Rheumatology San Francisco 2008/10/24-29 |
| 2008 | Water-soluble fullerene (C60) inhibits synovitis and bone resorption in rat collagen-induced arthritis through down-regulating inflammation and the osteoclastogenesis during the development of arthritis | Yudoh K. American College of Rheumatology San Francisco 2008/10/24-29 |
| 2008 | Fullerenes for Radical Control of your life. | Yamana S. International Cosmetic-Tech Conference & Exhibition（台湾静宜大学） Taichung/Taipei 2008/10/23-24 |
| 2008 | POSSIBILITY OF FULLERENE APPLICATION IN LASER TREATMENT | Fujimoto T. 17th Congress of the European Academy of Dermatology and Venereology Paris 2008/9/17-20 |
| 2008 | フラーレンのスキンケア素材としての有用性 | Ito M. 第26回 日本美容皮膚科学会 Osaka/Japan 2008/8/30-31 |
| 2008 | フラーレンとアンチエイジング | Ito M. 油化学若手の会 サマースクール Aichi/Japan 2008/8/6-7 |
| 2008 | Antimicrobial Activity of Fullerene and Its Derivatives | Aoshima H. 「ナノトキシコロジーアセスと微粒子・ナノチューブのバイオ応用」国際シンポジウム Sapporo/Japan 2008/6/16-17 |
| 2008 | 高度水酸化フラーレンによる酸化ストレスと脂肪細胞分化への抑制効果、及び、多分化能生細胞を含む皮膚組織モデルの活用 | Xio L. The 33rd Annual Meeting of Japanese Cosmetic Science Society Tokyo/Japan 2008/6/5-6 |
| 2008 | スクワラン溶解フラーレンによるヒト皮膚細胞障害への防御活性とヒト皮膚組織シワ防御効果の可能性 | Kato M. The 33rd Annual Meeting of Japanese Cosmetic Science Society Tokyo/Japan 2008/6/5-6 |
| 2008 | b-カロテン退色法によるフラーレン類の抗酸化能評価及びフラーレンによる抗酸化物質光分解抑制効果 | Aoshima H. The 33rd Annual Meeting of Japanese Cosmetic Science Society Tokyo/Japan 2008/6/5-6 |
| 2008 | Antimicrobial Activity of Fullerene and Its Derivatives | Aoshima H. ASM General Meeting Boston/USA 2008/6/1-5 |
| 2008 | 医療用レーザー創傷部の炎症性シグナルの検討 | Ito M. 第92次 日本法医学会総会 Nagasaki/Japan 2008/4/9-11 |
| 2008 | ESR analysis of Free radical generated by Fractional Resurfacing Laser | Fujimoto T. ASLMS 28th Annual Conference Florida 2008/4/2-6 |
| 2008 | 抗酸化成分“フラーレン”の事業化 製品名 Radical Sponge®（RS:ラジカルスポンジ） | Yamana S. The 88th Annual Meeting of the Chemical Society of Japan Tokyo/Japan 2008/3/26-30 |
| 2008 | Evaluation of Antioxidant Activity of Water-soluble Fullerene Derivatives and Natural Antioxidants by -Carotene Bleaching Assay | Kokubo K. The 34th Fullerene-Nanotubes General Symposium Nagoya/Japan 2008/3/3-5 |
| 2008 | Antimicrobial Activity of Fullerene and Its Derivatives | Aoshima H. The 34th Fullerene-Nanotubes General Symposium Nagoya/Japan 2008/3/3-5 |
| 2007 | Fullerenes for Radical Control of your life. | Yamana S. International Cosmetic-Tech Conference & Exhibition（台湾静宜大学） Taichung/Taipei 2007/11 |
| 2007 | Kinetic Study on Antioxidant Activity of Water-soluble [60]Fullerene and [60]Fullerene Epoxide by -Carotene Bleaching Assay | Kokubo K. The 33rd Fullerene-Nanotubes General Symposium Fukuoka/Japan 2007/7/11-13 |
| 2007 | フラーレンを使用した機能性化粧品向け美白成分の開発（香粧品におけるラジカルコントロールの必要性） | Matsubayasi K. フリーラジカル学会学術集会、日本過酸化脂質・フリーラジカル学会（スポンサード） Nagoya/Japan 2007/6/9-10 |
| 2007 | The Development of Cellulite Repressors : the Repressive Effects of Fullerene derivatives on Differentiation and Oil Droplet Accumulation in Preadipocytes | Kato M. The 32nd Annual Meeting of Japanese Cosmetic Science Society Tokyo/Japan 2007/6/7-8 |
| 2007 | New Derivatives of Fullerene by Highly Hydroxylation and γ-CD Clathrate Formation: Their Antioxidant Ability and Cytoprotective Effects on Human Skin Cells | Miwa N. The 32nd Annual Meeting of Japanese Cosmetic Science Society Tokyo/Japan 2007/6/7-8 |
| 2007 | 新しい色白剤開発と後期メラニン生成抑制 「女性外来（美容皮膚専門）における美白治療」～フラーレン含有新規化粧品の評価～ | Konishi N. 第106回 日本皮膚科学会総会（スポンサード） Yokohama/Japan 2007/4/20-22 |
| 2007 | Application of Fullerene as a Cosmetic Ingredient; Safety Evaluation and Antioxidative Activity | Aoshima H. The 87th Annual Meeting of the Chemical Society of Japan Osaka/Japan 2007/3/25-28 |
| 2007 | Antioxidant Activity of Wate r-Soluble Fullerenes by b-Carotene Bleaching Assay | Goto T. The 32nd Fullerene-Nanotubes General Symposium Nagoya/Japan 2007/2/13-15 |
| 2007 | Synthesis of Super Hydrophilic Fullerene Nanoparticle and Its Application to Cosmetic Ingredient and Polishing Slurry | Kokubo K. The 32nd Fullerene-Nanotubes General Symposium Nagoya/Japan 2007/2/13-15 |
| 2006 | Antioxidant Activity of Water-soluble Fullerenes on b-Carotene | Matsubayashi.k 第20回 カロテノイド研究談話会8（The 21st meeting of carotenoid study） Okinawa/Japan 2006/9/8-10 |
| 2006 | Antioxidant Activity of Water-soluble Fullerenes on b-Carotene | Takada, H The 31st Fullerene-Nanotubes General Symposium Mie/Japan 2006/7/12-14 |
| 2006 | Safety Evaluation of Fullerenes for Skin Application and Clinical Skin Lightning Effects of Fullerenes complex “Radical Sponge®” | Matsubayashi.k The 31st Fullerene-Nanotubes General Symposium Mie/Japan 2006/7/12-14 |
| 2006 | Whitening Mechanism and Permeability through the Skin of the PVP- Polymer-Entrapped Derivative of Fullerene | The 31st Annual Meeting of Japanese Cosmetic Science Society Tokyo/Japan 2006/6/8-9 |
| 2006 | Water-Soluble Fullerene “Radical Sponge®” as a New Cosmetics Ingredient: Potential Anti-oxidative Effects and Preclinical Safety Evaluation of Fullerene | Matsubayashi.k The 4th Society of Nano Science and Technology Kyoto/Japan 2006/5/19-21 |
| 2005 | Fullerene as “RadicalSponge” for Juvenile Skin Protection | Takada, H 2005 ANNUAL TECHNOLOGY SHOWCASE New York 2005/12 |
| 2005 | Development and Progress of Novel Anti-oxidant Cosmetic Ingredient | Matsubayashi.k 高機能性化粧品開発における最新動向及び有用性評価 Tokyo/Japan 2005/11 |
| 2005 | Water-Soluble Fullerene “Radical Sponge®” for Skin Care Cosmetics: Potential Anti-oxidative Effects and Safety Evaluation of Fullerene | Fujimoto, Y Nano Toxicology and Public assessment conference Sendai/Japan 2005/11 |
| 2005 | Draw Attention as New Cosmetic Ingredient “Fullerrene” | Matsubayashi.k The 1404 Seminar of Novel Medical Care Tokyo/Japan 2005/7 |
| 2005 | Biological Safety and Antimelanogenesis Activity of Fullerene | Miwa, N The 30th Annual Meeting of Japanese Cosmetic Science Society Tokyo/Japan 2005/6/2-3 |
| 2005 | Biological Safety and Antimelanogenesis Activity of Fullerene | Matsubayashi.k The 3rd Society of Nano Science and Technology Sendai/Japan 2005/5/8-10 |
| 2005 | INNOVATIVE ANTI-OXIDANT:FULLERENE (INCI#7587) IS AS “RADICALSPONGE” ON THE SKIN. ITS HIGH LEVEL OF SAFTY, STABILITY AND POTENTIAL AS PREMIER ANTI-AGING AND WHITENING COSMETIC INGREDIENT | In-COSMETICS Berlin/Germany 2005/4 |
| 2005 | Technology and Evidence of Novel Anti-oxidant Cosmetic Ingredient | Matsubayashi.k The 48th Annual Meeting of Japan Society of Plastic and Reconstructive Surgery Tokyo/Japan 2005/4 |
| 2005 | INNOVATIVE ANTI-OXIDANT:FULLERENE (INCI#7587) IS AS “RADICALSPONGE” ON THE SKIN. ITS HIGH LEVEL OF SAFTY, STABILITY AND POTENTIAL AS PREMIER ANTI-AGING AND WHITENING COSMETIC INGREDIENT | Matsubayashi.k The 7th Asian Society of Cosmetic Scientists Conference Bangkok/Thailand 2005/3 |
| 2005 | Fullerenes for “Radical Control” of your life Coming Soon! | Matsubayashi.k The 28th Fullerene-Nanotubes General Symposium Nagoya/Japan 2005/1 |
| 2004 | Better Effect of New Cosmetics After Laser Treatment | Takada, H 10th Congress, Asian-Pacific Association for Laser Shanghai/China 2004/11 |
| 2004 | Basic of Laser with Nano Material, Fullerene | Takada, H 15th congress, International YAG Laser Society Shanghai/China 2004/11 |
| 2004 | Inhibitory Effects of Fullerene Complex Radical Sponge on UV-/Lipid Hydroperoxide-Induced Cell Death of Keratinocytes and Metastasis/Invasion of Melanoma Cells | Takada, H The 27th Fullerene-Nanotubes General Symposium Tokyo/Japan 2004/7 |
| 2004 | Preventive Effect of Fullerene Complex Radical Sponge on Accumulation of Intracellular Lipid Droplets for Development of Anti-Cellulite Cosmetics | Suzuki, S The 27th Fullerene-Nanotubes General Symposium Tokyo/Japan 2004/7 |
| 2004 | Anti-Oxidant Effects of Water-soluble Fullerene Derivatives: Their Actions of Scavenging the Reactive Oxygen Species Derived from Ultraviolet B-Wave or Peroxylipid in Human Skin Keratinocytes | TIto, S The 29th Annual Meeting of Japanese Cosmetic Science Society Tokyo/Japan 2004/6 |
| 2004 | Anti-Oxidant Effects of Water-soluble Fullerene Derivatives: Their Actions of Scavenging the Reactive Oxygen Species Derived from Ultraviolet Ray or Peroxylipid in Human Skin Keratinocytes | Takada, H The 26th Fullerene-Nanotubes General Symposium Nagoya/Japan 2004/1/7-9 |
| 2022 | Protective effects of polyvinylpyrrolidone-wrapped fullerene against nitric oxide/peroxynitrite-induced cellular injury in human skin keratinocytes | International Journal of Medicinal Mushrooms 24 (9), 41-47 Aoshima H. et al. |
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| 2021 | Clinical evaluation of topical lotion containing 2-aza-8-oxohypoxanthine on skin barrier function against water loss. | Cosmetics 8(3), 83 Aoshima H. et al. |
| 2021 | Safety evaluation of 2-aza-8-oxohypoxanthine by in vitro skin sensitization and human tests. | Fundamental Toxicological Science 8(4), 123-133 Aoshima H. et al. |
| 2021 | The potential of 2-aza-8-oxohypoxanthine as a cosmetic ingredient. | Cosmetics 8(3), 6 Aoshima H. et al. |
| 2021 | Protective effects of polyvinylpyrrolidone-wrapped fullerene against nitric oxide/peroxynitrite-induced cellular injury in human skin keratinocytes | Journal of Nanoscience and Nanotechnology 21, 4579–4585 Saitoh Y. et al. |
| 2020 | Safety evaluation of 2-aza-8-oxohypoxanthine based on in vitro and human patch tests. | Fundamental Toxicological Science 7(5), 207-214 Aoshima H. et al. |
| 2016 | フラーレンの目立つ毛穴の減少：PGE2を介したメカニズムの可能性 | Medical Science Digest 42(14), 42-44 Aoshima H. et al. |
| 2016 | Potential suppressive effects of C60-fullerene derivatives on acquired immunity. | Nanoscale Research Letters Accepted Hirai T. et al. |
| 2016 | Protective effects of polyvinylpyrrolidone-wrapped fullerene against intermittent ultraviolet-A irradiation-induced cell injury in HaCaT cells | Journal of Photochemistry & Photobiology, B: Biology 163 (2016) 22-29 Yasukazu S. et. al. |
| 2015 | Hydroxylated Fullererne : a potential anti-inflammatory and anti-oxidant agent for preventing mouse preterm birth | American Journal of Obstetrics & Gynecology. 213(5), 708-717 Wakimoto T. et al. |
| 2014 | Reduction of conspicuous facial pores by topical fullerene: possible role in the suppression of PGE2 production in the skin | Journal of Nanobiotechnology 12, 6 Inui S. et al. |
| 2014 | Fullerene-C60 derivatives prevent UV-irradiation/TiO2-induced cytotoxicity on keratinocytes and 3D-skin tissues through antioxidant actions. | Journal of Nanoscience and Nanotechnology 14, 3285-3291 Kato S. et al. |
| 2013 | Photoprotective effects of inclusion complexes of fullerenes with polyvinylpyrrolidone. | Photodermatol Photoimmunol Photomed 29(4), 196-203 Murakami M et al. |
| 2013 | Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration. | Pharmazie 68(1), 54-57 Yamashita K. et al. |
| 2012 | フラーレンの抗酸化機能と化粧品への応用／フラーレンの安全性に関する最新知見と評価 | Bio Industry 3月号 29,3,39-45 Aoshima H. / Ito M. |
| 2012 | Polyhydroxylated fullerene C60(OH)44 suppresses intracellular lipid accumulation together with repression of intracellular superoxide anion radicals and subsequent PPARγ2 expression during spontaneous differentiation of OP9 preadipocytes into adipocytes. | Mol Cell Biochem 366, 191-200 Saitoh Y. et al. |
| 2012 | Inhibition of sebum production and propionibacterium acnes lipase activity by fullerenol, a novel polyhydroxylated fullerene: Potential as therapeutic reagent for acne. | The Journal of Cosmetic Science 63, 259-265 Inui S. et al. |
| 2012 | Induction of different reactive oxygen species in the skin during various laser therapies and their inhibition by fullerene. | Lasers Surg Med. 44(8), 685-694 Fujimoto T. et al |
| 2011 | Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. | Nature Nanotechnology 6(5)321-238 Yamashita K. et al. |
| 2011 | Fullerene-C60 incorporated in liposome exerts persistent hydroxyl radical-scavenging activity and cytoprotection in UVA/B-irradiated keratinocytes | Journal of Nanoscience and Nanotechnology 11(5), 3814-3823 Kato S. et al. |
| 2011 | Highly Hydroxylated Fullerene localizes at Cytoskeletons and inhibits Oxidative stress in Adipocytes and a Subcutaneous Adipose-tissue Equivalent | Free Radic Biol Med 51(7), 1376-89 Xiao, L. et al. |
| 2010 | Fullerene-C60/liposome complex: defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue. | Journal of Photochemistry and Photobiology B: Biology 98, 99-105 Kato S. et al. |
| 2010 | Defensive effects of fullerene-C60 dissolved in squalane against the 2, 4-nonadienal induced cell injury in human skin keratinocytes HaCaT and wrinkle formation in 3D-human skin tissue model. | Journal of Biomedical Nanotechnology 6, 1-7 Kato S. et al. |
| 2010 | Defensive effects of fullerene-C60/liposome complex against UVA-induced intracellular reactive oxygen species generation and cell death in human skin keratinocytes HaCaT, associated with intracellular uptake and extracellular excretion of fullerene-C60. | Journal of Photochemistry and Photobiology B: Biology 98, 144-151 Kato S. et al. |
| 2010 | Biological safety of water-soluble fullerenes evaluated by genotoxicity, phototoxicity studies, and pro-oxidant activity. | The Journal of Toxicological Science 35 (3), 401-409 Aoshima H. et al. |
| 2010 | The effect of squalane-dissolved fullerene-C60 on adipogenesis-accompanied oxidative stress and macrophage activation in a preadipocyte-monocyte co-culture system. | Biomaterials. 31, 5976-5985 Xiao, L. et al |
| 2010 | Clinical Evaluation of Fullerene-C60 Dissolved in Squalane for Anti-Wrinkle Cosmetics. | Journal of Nanoscience and Nanotechnology 10, 6769-6774 Kato S. et al. |
| 2010 | 水酸化フラーレンナノ粒子の合成方法とその応用～化粧品用添加剤から杉花粉アレルゲン除去まで～ | 化学装置 7月号, 49-53 Kokubo K. et al. |
| 2010 | フラーレン(C60)の関節炎に対する抗炎症・破骨細胞分化・機能抑制効果 | グルコサミン研究 6, 61-67 Aoshima H. et al. |
| 2010 | Novel polyhydroxylated fullerene suppresses intracellular oxidative stress together with repression of intracellular lipid accumulation during the differentiation of OP9 preadipocytes into adipocytes. | Free Radical Research 44(9), 1072-1081. Saitoh Y. et al. |
| 2010 | Fullerene-Polyvinylpyrrolidone Clathrate Localizes in the Cytoplasm to Prevent Ultraviolet-A Ray-Induced DNA-Fragmentation and Activation of the Transcriptional Factor NF-kappa B | Journal of Cellular Biochemistry 9999, 1-12 Xiao, L. et al. |
| 2010 | Improvement of acne vulgaris by topical fullerene application: Unique impact on skin care | Nanomedicine: Nanotechnology, Biology, and Medicine. 7, 238-241 Inui S. et al. |
| 2010 | Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages. | Journal of Photochemistry and Photobiology B: Biology. 102, 69-76 Saitoh Y. et al. |
| 2010 | Facile and Scalable Synthesis of Highly Hydroxylated Water-Soluble Fullerenol as a Single Nanoparticle. | Free Radic Biol Med 4(2), 204-215 Kokubo K. et al. |
| 2009 | 抗酸化成分フラーレンの事業化 | 未来材料 9, 1, 63-65 Yamana S., Ito M. |
| 2009 | Biological Safety of LipoFullerene composed of Squalane and Fullerene-C60 upon Mutagenesis, Photocytotoxicity, and Permeability into the Human Skin Tissue. | Basic & Clinical Pharmacology & Toxicology 104(6), 483-487 Kato S. et al. |
| 2009 | Biological safety of liposome-fullerene consisting of hydrogenated lecithin, glycine soja sterols, and fullerene-C60 upon photocytotoxicity and bacterial reverse mutagenicity. | Toxicology and Industrial Health 25(3), 197-203 Kato S. et al. |
| 2009 | Antimicrobial Activity of Fullerenes and Their Hydroxylated Derivatives | Biocontrol Science 14 (2), 69-72 Aoshima H. et al. |
| 2009 | Highly-hydroxylated or g-cyclodextrin-bicapped water-soluble derivative of fullerene: the antioxidant ability assessed by electron spin resonance method and b-carotene bleaching assay. | Bioorganic & Medicinal Chemistry Letters 19 (18), 5293 Kato S. et al. |
| 2009 | Safety evaluation of highly purified fullerenes: based on screening of eye and skin damages. | The Journal of Toxicological Science 34 (5), 555-562 Aoshima H. et al. |
| 2009 | フラーレン類の抗酸化能評価および汎用化粧品成分の光分解抑制効果 | 日本香粧品学会誌 33 (3), 149-154 Aoshima H. et al. |
| 2009 | Preparation of Hydrophilic Nanoparticles of C60 with High Resistance to Aggregation during Storage, using 2-Hydroxypropyl-b-cyclodextrin. | Chemistry Letters 38 (11), 1104-1105 Iohara D. et al. |
| 2008 | Facile synthesis of highly water-soluble fullerenes more than half-covered by hydroxyl groups | ACS NANO 2, 2, 327-333 Kokubo K. et al. |
| 2007 | Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVA-induced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues | Archives of Dermatological Research 299, no5-6, 245-257 Xiao, L. et al. |
| 2007 | Water-soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis via down-regulation of chondrocyte catabolic activity and inhibition of cartilage degeneration during disease development | Arthritis and Rheumatism 56, 10, 3307-3319 Yudoh K. et al. |
| 2007 | Involvement of free radicals followed by the activation of phospholipase A2 in the mechanism that underlies the combined effects of methamphetamine and morphine on subacute toxicity or lethality in mice: Comparison of the therapeutic potential of fullerene, mepacrine, and cooling | Toxicology 236, 3, 149-57 Mori, T. et al |
| 2006 | The Water-Soluble Fullerene Derivative “Radical Sponge・Exerts Cytoprotective Action against UVA Irradiation but Not Visible-Light-Catalyzed Cytotoxicity in Human Skin Keratinocytes | Bioorganic & Medicinal Chemistry Letters 16, 1590-1595 Xiao, L. et al |
| 2006 | Preclinical Studies on Safety of Fullerene upon Acute Oral Administration and Evaluation for No Mutagenesis | Toxicology 225, 48-54 Mori, T. et al |
| 2006 | Innovative Anti-Oxidant: Fullerene(INCI#: 7587) is as Radical Sponge on the skin. Its High Level of Safety, Stability and Potential as Premier Anti-Aging and Whitening Cosmetic Ingredient | Fullerenes, Nanotubes, and Carbon Nanostructures 14, 335-341 Takada, H. et al. |
| 2006 | Antioxidant Activity of Supramolecular Water-soluble Fullerenes Evaluated by β‐Carotene Bleaching Assay | Bioscience, Biotechnology, and Biochemistry, Oct/2006 70, 12, 3088-3093 Takada, H. et al. |
| 2005 | Anti-Oxidant Effects of Water-soluble Fullerene Derivatives against Ultraviolet Ray or Peroxylipid through Their Action of Scavenging the Reactive Oxygen Species in Human Skin Keratinocytes | Biomedicine & Pharmacotherapy 59, 351-358 Xiao, L. et al |
| 2004 | ナノテクノロジー素材フラーレン誘導体の抗酸化作用 | 新有用性化粧品の開発 -Technology of Evidence Based Cosmetics- 第6章, 291-308 Takada, H. et al. |
| 2003 | ナノテク素材フラーレン誘導体の抗酸化効果 | Fragrance Journal 32, 40-48 Maeda, K. et al. |
| 2003 | ナノテクノロジー新素材：フラーレンを用いた化粧品による美肌革命の可能性 | BIO INDUSTRY 20, 82-90 Matsubayashi, K. et al. |
| 2003 | フラーレン誘導体による活性酸素の消去－ナノテク新素材の美肌化粧品への応用－ | 美肌・皮膚防御とバイオ技術-Rejuvenation and Skin Protection, and Biotechnology- 第4編, 第20章, 229-238 Miwa, N. ed. |